For most guitarists the main problem with the hand will be fatigue and the inevitable cramping that follows when we play through it. The left hand tends to suffer more because pressing onto the fretboard requires more work from the muscle.
The main causes are related to technique, excess tension in the hand and simply playing too much. The most immediate problem is that your playing is severely restricted, there is no way you can play your instrument fluently if there is excess myofascial tension in your hand, arm or shoulder.